Selected publications on applying pain reflex

1. Utility of Nociceptive Flexion Reflex Threshold, Bispectral Index, Composite Variability Index and Noxious Stimulation Response Index as measures for nociception during general anaesthesia.
von Dincklage F, Correll C, Schneider MH, Rehberg B, Baars JH.
Anaesthesia. 2012 Aug; 67(8):899-905.

2. Spinal modulation of nociception by music.
Roy M, Lebuis A, Hugueville L, Peretz I, Rainville P.
Eur J Pain. 2012 Jul;16(6):870-7.

3. Clinical pain and experimental pain sensitivity in progressive supranuclear palsy.
Stamelou M, Dohmann H, Brebermann J, Boura E, Oertel WH, Höglinger G, Möller JC, Mylius V.
Parkinsonism Relat Disord. 2012 Jun;18(5):606-8.

4. Functional exploration for neuropathic pain.
Maarrawi J, Mertens P, Peyron R, Garcia-Larrea L, Sindou M.
Adv Tech Stand Neurosurg. 2011;37:25-63.
5. A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
Ing Lorenzini K, Besson M, Daali Y, Salomon D, Dayer P, Desmeules J.
Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):357-64.
6. Pain sensitivity and clinical progression in Parkinson's disease.
Mylius V, Brebbermann J, Dohmann H, Engau I, Oertel WH, Möller JC.
Mov Disord. 2011 Oct;26(12):2220-5.
7. Cutaneous silent period in fibromyalgia.
Sahin O, Yildiz S, Yildiz N.
Neurol Res. 2011 May;33(4):339-43.
8. Association of nociceptive responsivity with clinical pain and the moderating effect of depression.
Ang DC, Chakr R, France CR, Mazzuca SA, Stump TE, Hilligoss J, Lengerich A.
J Pain. 2011 Mar;12(3):384-9.
9. Noneffect of manual needle acupuncture on experimental pain parameters in healthy young men.
Micalos PS, Pak SC.
J Altern Complement Med. 2011 Jan;17(1):57-61.
10. Apomorphine effect on pain threshold in Parkinson's disease: a clinical and positron emission tomography study.
Dellapina E, Gerdelat-Mas A, Ory-Magne F, Pourcel L, Galitzky M, Calvas F, Simonetta-Moreau M, Thalamas C, Payoux P, Brefel-Courbon C.
Mov Disord. 2011 Jan;26(1):153-7.
11. Are there sex differences in affective modulation of spinal nociception and pain?
Rhudy JL, Bartley EJ, Williams AE, McCabe KM, Chandler MC, Russell JL, Kerr KL.
J Pain. 2010 Dec;11(12):1429-41.
12. Monitoring of the responsiveness to noxious stimuli during sevoflurane mono-anaesthesia by using RIII reflex threshold and bispectral index.
von Dincklage F, Velten H, Rehberg B, Baars JH.
Br J Anaesth. 2010 Jun;104(6):740-5.
13. The effect of the menstrual cycle on affective modulation of pain and nociception in healthy women.
Rhudy JL, Bartley EJ.
Pain. 2010 May;149(2):365-72.
14. Cognitive-behavioral therapy attenuates nociceptive responding in patients with fibromyalgia: a pilot study.
Ang DC, Chakr R, Mazzuca S, France CR, Steiner J, Stump T.
Arthritis Care Res (Hoboken). 2010 May;62(5):618-23.
15. Monitoring of the responsiveness to noxious stimuli during anaesthesia with propofol and remifentanil by using RIII reflex threshold and bispectral index.
von Dincklage F, Hackbarth M, Mager R, Rehberg B, Baars JH.
Br J Anaesth. 2010 Feb;104(2):201-8.
16. Effects of sevoflurane and propofol on the nociceptive withdrawal reflex and on the H reflex.
Baars JH, Mager R, Dankert K, Hackbarth M, von Dincklage F, Rehberg B.
Anesthesiology. 2009 Jul;111(1):72-81.
17. Cannabinoid-induced effects on the nociceptive system: a neurophysiological study in patients with secondary progressive multiple sclerosis.
Conte A, Bettolo CM, Onesti E, Frasca V, Iacovelli E, Gilio F, Giacomelli E, Gabriele M, Aragona M, Tomassini V, Pantano P, Pozzilli C, Inghilleri M.
Eur J Pain. 2009 May;13(5):472-7.
18. Introduction of a continual RIII reflex threshold tracking algorithm.
von Dincklage F, Hackbarth M, Schneider M, Baars JH, Rehberg B.
Brain Res. 2009 Mar 13;1260:24-9.
19. Comparison of the nociceptive flexion reflex threshold and the bispectral index as monitors of movement responses to noxious stimuli under propofol mono-anaesthesia.
von Dincklage F, Send K, Hackbarth M, Rehberg B, Baars JH.
Br J Anaesth. 2009 Feb;102(2):244-50.
20. Effects of opioid blockade on nociceptive flexion reflex thresholds and nociceptive responding in hypertensive and normotensive individuals.
Edwards L, Ring C, France CR, McIntyre D, Martin U.
Int J Psychophysiol. 2008 Aug;69(2):96-100.
21. Mirtazapine decreases the pain feeling in healthy participants.
Arnold P, Vuadens P, Kuntzer T, Gobelet C, Deriaz O.
Clin J Pain. 2008 Feb;24(2):116-9.
22. Pharmacokinetic and pharmacodynamic properties of buprenorphine after a single intravenous administration in healthy volunteers: a randomized, double-blind, placebo-controlled, crossover study.
Escher M, Daali Y, Chabert J, Hopfgartner G, Dayer P, Desmeules J.
Clin Ther. 2007 Aug;29(8):1620-31.
23. Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study.
Gerdelat-Mas A, Simonetta-Moreau M, Thalamas C, Ory-Magne F, Slaoui T, Rascol O, Brefel-Courbon C.
J Neurol Neurosurg Psychiatry. 2007 Oct;78(10):1140-2.
24. Anger management style and endogenous opioid function: is gender a moderator?
Bruehl S, al'Absi M, France CR, France J, Harju A, Burns JW, Chung OY.
J Behav Med. 2007 Jun;30(3):209-19.
25. Constitutive cyclooxygenase-2 is involved in central nociceptive processes in humans.
Martin F, Fletcher D, Chauvin M, Bouhassira D.
Anesthesiology. 2007 May;106(5):1013-8.
26. Nociceptive flexion reflex and pain rating responses during endogenous opiate blockade with naltrexone in healthy young adults.
France CR, al'Absi M, Ring C, France JL, Harju A, Wittmers LE.
Biol Psychol. 2007 Apr;75(1):95-100.
27. Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients.
Sandrini G, Rossi P, Milanov I, Serrao M, Cecchini AP, Nappi G.
Cephalalgia. 2006 Jul;26(7):782-9.
28. Effects of a brief coping skills training intervention on nociceptive flexion reflex threshold in patients having osteoarthritic knee pain: a preliminary laboratory study of sex differences.
Emery CF, Keefe FJ, France CR, Affleck G, Waters S, Fondow MD, McKee DC, France JL, Hackshaw KV, Caldwell DS, Stainbrook D.
J Pain Symptom Manage. 2006 Mar;31(3):262-9.
29. The lower limb flexion reflex in humans.
Sandrini G, Serrao M, Rossi P, Romaniello A, Cruccu G, Willer JC.
Prog Neurobiol. 2005 Dec;77(6):353-95.
30. Affective modulation of nociception at spinal and supraspinal levels.
Rhudy JL, Williams AE, McCabe KM, Nguyen MA, Rambo P.
Psychophysiology. 2005 Sep;42(5):579-87.
31. The influence of acute anxiety on assessment of nociceptive flexion reflex thresholds in healthy young adults.
French DJ, France CR, France JL, Arnott LF.
Pain. 2005 Apr;114(3):358-63.
32. Alteration of the spinal modulation of nociceptive processing in patients with irritable bowel syndrome.
Coffin B, Bouhassira D, Sabaté JM, Barbe L, Jian R.
Gut. 2004 Oct;53(10):1465-70.
33. Effects of nimesulide on nitric oxide-induced hyperalgesia in humans--a neurophysiological study.
Sandrini G, Tassorelli C, Cecchini AP, Alfonsi E, Nappi G.
Eur J Pharmacol. 2002 Aug 30;450(3):259-62.
34. The effects of isoflurane on repeated nociceptive stimuli (central temporal summation).
Petersen-Felix S, Arendt-Nielsen L, Bak P, Fischer M, Bjerring P, Zbinden AM.
Pain. 1996 Feb;64(2):277-81.
35. Psychophysical and electrophysiological responses to experimental pain may be influenced by sedation: comparison of the effects of a hypnotic (propofol) and an analgesic (alfentanil).
Petersen-Felix S, Arendt-Nielsen L, Bak P, Fischer M, Zbinden AM.
Br J Anaesth. 1996 Aug;77(2):165-71.
36. Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain.
Petersen-Felix S, Arendt-Nielsen L, Bak P, Roth D, Fischer M, Bjerring P, Zbinden AM.
Br J Anaesth. 1995 Jul;75(1):55-60.
37. Objective evaluation of pain perception in patients with schizophrenia.
Guieu R, Samuélian JC, Coulouvrat H.
Br J Psychiatry. 1994 Feb;164(2):253-5.
38. Capsaicin-induced central facilitation of a nociceptive flexion reflex in humans.
Grönroos M, Pertovaara A.
Neurosci Lett. 1993 Sep 3;159(1-2):215-8.
39. Central analgesic activity of ibuprofen. A neurophysiological study in humans.
Sandrini G, Ruiz L, Capararo M, Garofoli F, Beretta A, Nappi G.
Int J Clin Pharmacol Res. 1992;12(4):197-204.
40. Central analgesic effect of acetaminophen but not of aspirin.
Piletta P, Porchet HC, Dayer P.
Clin Pharmacol Ther. 1991 Apr;49(4):350-4.
41. Central analgesic effect of paracetamol.
Piletta P, Porchet HC, Dayer P.
Med. Wochenschr. 1990; 120:1950?1951.
42. Central analgesic effect of ketoprofen in humans: electrophysiological evidence for a supraspinal mechanism in a double-blind and cross-over study.
Willer JC, De Broucker T, Bussel B, Roby-Brami A, Harrewyn JM.
Pain. 1989 Jul;38(1):1-7.
43. Studies on pain. Effects of morphine on a spinal nociceptive flexion reflex and related pain sensation in man.
Willer JC.
Brain Res. 1985 Apr 1;331(1):105-14.
44. Comparative study of perceived pain and nociceptive flexion reflex in man.
Willer JC.
Pain. 1977 Feb;3(1):69-80.
45. Pharmacological modulations on the nociceptive flexion reflex in man.
Willer JC, Bathien N.
Pain. 1977 Apr;3(2):111-9.

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